Basically I would like to enable RTTI support but I am wondering if using gnustl_static will cause issues with the Cocos2d-x engine. If so, what are those issues? Thanks.

We have anabled it in our project (Android, Win), but no issue yet.

If somebody has issue, please report it.

Thanks

If you need RTTI, I don't think you should replace stl lib.

NDK-ROOT/docs/CPLUSPLUS-SUPPORT.html says:

Similarly, the NDK toolchain supports C++ RTTI (RunTime Type Information)
since NDK r5, but all C++ sources are built with -fno-rtti by default for
compatibility reasons. To enable it, add the following to your module
declarations:

    LOCAL_CPPFLAGS += -frtti

Or more simply to your Application.mk:

    APP_CPPFLAGS += -frtti